Amicus Therapeutics: A Bio-pharmaceutical Company Dealing Mainly With Chaperone

Amicus Therapeutics went public in the year 2007. Before that, it was sourcing its funding from a variety of Venture Capital firms. The company was founded on February 4th, in the year 2002. It’s located in the State of New Jersey.

The company mainly has developed a focus revolving around lysosomal storage disorders and other rare orphan diseases. The company mainly develops its pharmaceutical products based on Chaperone-Advanced Replacement Therapy commonly known as CHART. It has also focused on coming up with Enzyme Replacement Therapies (ERTs). Interesting to note, in the year 2014, the company, Amicus bio-pharmaceuticals was considered as being in possession of a wide range of small molecule pharmacological chaperones among the pharmaceutical industries.


For instance, the company had sold a pharmacological chaperone treatment for Fabry Disease commonly known as migalastat which used the trade name of Galafold. The drug mainly is used to make endogenous mutant alpha-galactosidase stable. Amicus Therapeutics has also partnered with other pharmaceutical companies such as GlaxoSmithKline (gsK) and JCR Pharmaceutical from the year 2010 to 2013 to research and deeply study about the co-formulation with recombinant alpha-galactosidase.


Amicus Therapeutics encountered financial challenges in the year 2009 when one of its funding partner, Shire, ended a contract. After that, Amicus Therapeutics faced significant setbacks although it managed to survive by all means necessary using funds from the initial contract with Shire. The firm was also forced to lay off some of the workers. For instance, about 20 percent of the total workforce was reduced.


In the year 2013, Amicus Therapeutics successfully purchased Callidus Biopharma which was mainly focused on developing therapy treatment for Pompe disease. Callidus Biopharma was the main competitor of Amicus Therapeutics. The purchase meant that proprietary materials and intellectual property of Callidus bio pharma now belonged to Amicus therapeutics.


The CEO of the company has been John F. Crowley since the year. Through his exquisite managerial skills, he has been able to lead the firm through financial challenges. Amicus Therapeutics has been able to grow exponentially over the years. Its specialty in chaperone related therapeutics has made the firm earn recognition.


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Success Academy launches a free online portal

Founded by Eva Moskowitz who is also the Chief Executive Officer, Success Academy is the New York City’s largest charter school network began a decade ago, Moskowitz had two goals: Start top-performing schools as well as work towards improving the American education system.


The CEO has undertaken an ambitious plan to expand Success Academy with the new online platform. The platform aimed at growing the institution’s network footprint ahead of the largest district school in America.


The free portal unveiled by Moskowitz and other Success Academy leaders from their headquarters in Lower Manhattan was dubbed the “Success Academy Education Institute.” The portal provides access to teacher development strategies as well as employing the curriculum at the 41 schools of Success Academy across the city.


Eva Moskowitz noted that many kids across the country are in schools where they are not taught to read or write as well as do mathematics and science at the core level. As a result, Success Academy was destined to be part of the solution.


Success Academy’s track record speaks volumes. The institution closed the achievement gap and improved the academic outcomes of low-income students. As a result, the school won the $250,000 Broad Prize meant for college preparedness programs that include scholarships and campus visits.


The online platform provides the charter network’s literacy curriculum for kindergarten to the fourth grade. It was the initial step to introduce teachers to the Success Academy mantra across the country. Besides, the network has a plan to launch a teacher-training facility at Hudson Yards in Manhattan and a school lab for students in kindergarten through eighth grade.


Success Academy is where 76 percent of the over 14,000 students are low-income, and 93 percent are African-American. Also, its middle and elementary schools were amongst the top 10 percent of campuses statewide on math, English, as well as science tests the previous year.


The Success Academy chief academic officer, Michele Caracappa said that if the institution could have had one resource, then it would have been the books. He adds that they had spent countless hours hand-picking the books for Success Academy.

College Admissions: What Every High School Scholar — and Parent — Should Know

How End Citizens United Plans to Achieve its Goal

End Citizens United was featured in an article that appeared on MSNBC two years ago. Richard Carbo is the director of communications for the group. He said that they had a pronged mission. End Citizens United backs candidates who want to see reforms in campaign finance and those who oppose dark-money groups. He added that many PACs only focused on one side and ignored the other.


The ultimate goal is the passing of an amendment to the Constitution to overturn the Citizens United decision that the Supreme Court made in 2010. The ruling allowed political candidates to receive unlimited funding from donors and super PACs. The PAC has a petition for Congress to pass the law that has received more than half a million signatures. Their goal of overturning the Supreme Court decision will not be easy. They are prepared to fight for it. This is because an amendment to the constitution requires it to be passed by two-thirds of Congressmen and members of the House.


Carbo is confident that the millions of dollars that they will raise will have an impact on the House race. The money will be used to buy advertising so that more people become aware. The PAC has an expenditure arm that is dedicated to back candidates through polling, mail, and advertisements on television. End Citizens United does not back Republicans because the party’s leaders in Congress are opposed to the idea of overturning the decision. The PAC is based in Washington D.C so that they can be more involved in legislation. It is made up of only five members of staff including Reed Adamson and Valerie Martin who are both senior advisers.


End Citizens United is on course to raise $35 million before the midterm Congress elections next year. They raised $4 million dollars during the first quarter of 2017 according to their fundraising data. The last election was their first election cycle. They managed to meet their target of twenty-five million. A huge percentage of the people who gave to the PAC this year were doing it for the first time. Tiffany Muller is the executive director and President of the PAC. Tiffany said that a hundred thousand people contributed the sum. She mentioned that the average contribution for the year was $12.


Muller noted that many of them were people who felt that their voice was not heard because those who had a lot of money were the ones who influenced the outcome. She explained that these people felt that they had a way of fighting back through End Citizens United. End Citizens United has hinted that the candidates that it will support include Jon Tester from Montana and Sherrod Brown of Ohio.




Karl Heideck

     A litigator is an appointed counsel, attorney, counsel, counsel representing a party, lead counsel, legal adversary or legal opponent. They are popular in the law field. They are to prosecute or defend a legal action. A litigator spends a great deal of time in the courtroom and lawsuits. A litigator’s salaries is just over $98,000. You have to go through special litigation training to become a litigator. These programs are offered in law school. You must receive a Juris Doctor (J.D) to work as a litigator. The Juris Doctor program allows you to study in Civil procedure, Constitutional law,Property and torts, Criminal law and Contracts. They have to graduate from an accredited law school and pass the state-mandated bar exam. They have to be licensed in the state the wish to practice. This requires them to take the exam every time the move to a new state. Its also good to continue education so litigators can keep up with new and changing laws.

Karl Heideck is an attorney that’s experienced in litigation, compliance and risk management review. He received his Bachelor of Arts degree from Swarthmore College. He received his J.D from Temple University- James E Beasley School of Law. Karl currently practices law in Philadelphia. He works for Pepper Hamilton LLP. While in law school, Karl Heideck worked as a Certified Legal Intern for the Montgomery County District Attorney. He assisted ADA’s in the pre-trials division with hearings and preparation. He also assisted with research for a pending homicide case. Heideck has a wide range of experience. Although Karl Heideck has a huge area of practice, he focuses a lot on complex commercial litigation, along with matters involving banking and subprime litigation. Karl also assisted with the discovery in major pharmaceutical litigation by helping review the client’s documents. Karl Heideck is very successful. He has helped plenty of client win cases.

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Don Ressler And Adam Goldenberg Have A Unicorn Company With A New Name

Don Ressler and his partner Adam Goldenberg are always constantly at work to keep their company, JustFab ahead of the competition with their innovative sales and high-tech changes. That’s why they decided to rename it just a few months ago to TechStyle Fashion Group because it combined trendy fashion with high end data analytics. But even more so this company went from relying on seed funding from Matrix Partners, Crosscut Ventures and Passport Capital to having its own cash flow in only 4 years, and its last round of venture capital put its total value over $1 billion, making it a unicorn. For Ressler, becoming a unicorn is just one milestone to point to in a long road of fashion development on While they have now introduced brick and mortar stores for their brand, they still believe in the power of fashion e-commerce to disrupt traditional shopping.

Don Ressler has a background in online marketing that started in the early 1990s. He consulted for various clients that harnessed the power of web design for marketing, but then he started his own sales platform at After several years running this company, Ressler sold it to Intermix Media, a well-known digital media agency in Los Angeles. He was hired as an executive and while there he met another young executive who had designed his own gaming advertising network named Adam Goldenberg. The two took their enthusiasm for e-commerce and marketing and began putting together more platforms under Intermix Media’s roof.

Ressler and Goldenberg’s first success as partners was Alena Media, an Intermix Media subsidiary that sold health and beauty supplies and started the Hydroderm brand. The company was shut down after News Corporation purchased in Intermix Media in 2005. Later that year they started their own network at Intelligent Beauty, and with that a whole new line of cosmetic brands emerged. In 2010 Ressler and Goldenberg decided to try something brand new on They launched a fashion sales company even though it wasn’t in their line of expertise. But since they had the marketing expertise and seed funding, they were able to launch it and bounce ideas that helped it take off on celebrities and fashion experts. JustFab began growing rapidly and to this day it’s generated billions in profits at

Get Rid of Your Rubbish-Quick!

Nothing is worse than having to look at a pile of unsightly rubbish but it can be quite an ordeal to get rid of it. It’s just easier to get it taken away by a professional who is equipped with the tools to do it. Hiring a rubbish removal service can not only save you a lot of time and hassle, but it can also be a cheaper option. When seeking the right service, don’t be afraid to ask questions and make sure that they can remove what you are trying to unload. Ask about any promotions or package options they my have as well as how long it will take to get them to pick up your rubbish. It also doesn’t hurt to read reviews on companies and ask your neighbors for their opinion of the rubbish removal services they have tried.


Clearabee was founded in 2012 and has providing their quality rubbish removal service since 2013. They are the largest man and van type of rubbish clearance company in the UK with over 165 employees and 65 vans. They offer a very convenient skip bag service as well as a Beeloyal program that gives their customers a 10% credit towards their qualifying orders on rubbish removal.


Clearabee is a nationwide company that can even guarantee that your rubbish will arrive safely at a waste disposal site. They are also open 7 days a week and they offer 24/7 online bookings. Clearabee will even pick up rubbish on the weekends and at night.

George Soros and the Open Society Foundations’ Political Prowess

You can’t talk about American politics without at least mentioning the work of renowned philanthropist and invest George Soros. George Soros has a reputation depending on who you ask. To Democrats he is one of their strongest backers, a billionaire who is willing to put his money and his reputation toward the greater good. Soros has personally given countless millions towards spreading social justice and progressive democracy around the globe, including here at home in the U.S.A. According to the right wing, however, George Soros is a shadow puppet who is constantly trying to subvert their conservative values. No matter how you view him, George Soros is returning to the political arena in the wake of 2016’s contentious election.

We are now living in a political America that has completely divided itself. On one side you have President Trump and his right wing. On the other side you have Democrats who are staunchly opposing Trump’s subversion of America’s global standing, fight for equality, and push toward climate change. George Soros personally jumped into the political fray during the election, donating $25+ million toward Hillary Clinton’s campaign as well as other down ballot tickets on the Democratic platform. Soros had previously been relatively quiet in mainstream American politics following his work in the 2004 election. Soros had vowed to step aside and tone down how he contributed. However, it appears that President Trump serves as a personal affront to Soros and everything that the progressive could value. So he is back. Visit Project Syndicate to learn more about George.

You need only look at George Soros and his Open Society Foundations in order to get a grip on what his goal is in the world. Soros wants to find ways to bring social justice, democracy, and true equality to as many countries as possible. That is why the Open Society Foundations has been such an important philanthropic endeavor. This foundation took particular hold during the Ferguson protests only a couple of years ago. When Officer Wilson shot and killed one Michael Brown, Soros’ grassroots funding came to life. Protests erupted around the nation and we were forced to take a closer look at the way police officers treat minorities in certain cities. The results were astounding, horrific, and important to verify.

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You can talk to Kenneth Zimmerman, the director at Open Society Foundation, in order to find out just what George Soros has in mind for his legacy. Zimmerman says, “Our DNA includes a belief that having people participate in government is indispensable to living in a more just, inclusive, democratic society.” Zimmerman’s eloquent explanation of the goals for Mr. Soros and the Open Society Foundations are enlightening and something that everybody should be able to get behind for the better of society. Know more on about George Soros.

Norman Pattiz: Legendary Radio Entrepreneur

Norman J. Pattiz is one of the most renowned names in radio. For decades, he’s produced some of America’s top entertainment news providers. His career has numerous unparalleled achievements. He’s also founded some of the biggest brands in radio and podcast history. In 2009, the National Radio Hall of Fame inducted Mr. Pattiz.

He is the founder and Executive Chairman of PodcastOne, the largest podcast network in the world. He’s produced shows with dozens of celebrities, including former NBA All-Star Shaquille O’Neal and WWE superstar Chris Jericho. Due to his many successes, he’s also been a part of several boards of directors and committees.

Crunchbase revealed that Norman Pattiz served on the Broadcasting Board of Governors, appointed by Presidents Clinton and Bush. He also created Radio Sawa and Alhurra Television. He’s the most respected authority when it comes to anything and everything radio and podcast related.

Recently, Mr. Norman Pattiz’s company, PodcastOne, along with Edison Research studied the effects of podcast advertising. The study focused on the impact of advertising during podcast shows. Since podcasts are fairly new, many large corporations haven’t invested as much time into exploring their potential. The study proved that podcast advertising can have a positive effect on consumers. Learn more about Norman Pattiz:

The study involved five major national brands that spanned several categories. The study was the first of its kind. It contained pre- and post-campaign results for all brands. The study showed a significant increase in consumers’ ability to recall a specific message. For some, it even persuaded them to try the product.

All areas and brands involved in the study saw a rise in the post-campaign results. For some, the results rose by more than one-third. Those who weren’t sure about certain products before said that they were “very likely” to consider buying that particular brand.

Over the course of last year, Edison Research conducted three studies. The brands used in each study were of different recognition levels; meaning some brands were well-known while the others weren’t. After the study, all brands were known.

Each brand’s campaign ran for four to six weeks. The results showed that no matter the purpose of the advertisement, whether to launch a new message or increase awareness, each brand succeeded to some degree. Norman Pattiz mentioned the importance of independently verifying that the podcast format does impact consumer decisions.

Success Academy Continues To Succeed

Success Academy is a network of charter schools for kids in New York City and was established in 2006. It contains 32 schools with over 9,000 students. It continues to grow with 13 more schools to open soon. The students are getting good test scores and people are noticing it. Their scores of 64 percent in English and 94 percent in math were much higher compared to other New York schools.

Success Acadamy is located in the poor community and to outperform the wealthier kids in the suburbs is raising eyebrows across the state. The students wear uniforms to school and are considered scholars. The school hours and season are longer than most schools. This allows more instruction time and more learning for the students. The school emphasizes discipline and the students understand that they are accountable for their success. This type of new culture is raising the expectations from both the parents and their children. Their curriculum is very detailed for each grade. They encourage students to work well with one another. The teachers use thought provoking ideas to challenge the minds of their students. Reading is highly encouraged and the students are provided with iPads that contains many books. The teachers are well trained to understand the concept of teaching in the Success Acadamy. They need to complete a four week training session under the supervision of school leaders. The teachers are compensated well for their hard work. They get paid more than other districts since they work more hours.

Teachers are provided with assistants to reach more students. There is more communication than other districts between teachers and parents. Parents being more involved helps homework getting done, projects being finished on time, and other tasks being completed. Not only is the state of New York taking the notice, but the country as well. With the nation’s average test scores being so low, compared to other big countries, there needs to be more schools like the Success Academy. Our future depends on it.

Jim Tananbaum Top 100 Investor

Jim Tananbaum with over 25 years of experience in investing and building healthcare companies, is a CEO and founder of Foresite Capital a healthcare growth equity firm based in San Francisco with an office to in New York. Jim’s other major investments include Amira Pharmaceuticals, Healtheon, among others. He holds a B.S.E.E. from Yale University, an MD from Harvard Medical School not forgetting an MBA in business from Harvard Business School.

According to the release from Biz Journals, 2017 Midas list, Jim Tananbaum appears among the top one hundred investors. It reveals that it is hard for a venture capital investor to stay on top of their game as these calls for the risk taking, calculations, and being lucky.In order to rank and achieve a deal metric ranking against competing investors, a summed score, which determines the ranking for each VC is determined too.

Put together, the rankings from a transaction parameter and deal count score, are reviewed by experienced investors and experts. By so doing this is used to determine a venture capitalist’s position on The Midas List. As for Jim’s appearance on the Midas list is a light show that Jim Tananbaum has the qualities to be a top investor.

Furthermore, Forest site capital health care has hit the headlines of San Francisco Business Wire through the press release that published the ability of it to hire Dr. Molly He as a venture partner who happens to be former and worked as the senior director at Illumina. He also worked for 15 years in Genomic and Pharmaceutical research and development. Jim termed Dr. He as a respected scientific researcher in the area of next-generation sequencing and her presence on the board is welcomed by his team.

Foresite Capital is focused on providing a platform to both the private and public markets through growth capital to emerging healthcare leaders with unstable products and services in other healthcare sectors. For over the last 20years, Dr. Jim has founded and given a hand to the growth of healthcare franchises in parts of the healthcare’s economy. Jim Tananbaum is also a co-founder of GelTex Pharmaceuticals, which brought into the market two drugs, being later sold for $1.6 billion.

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